The Connectome

Lead investigators

Hanspeter Pfister (SEAS ), Jeff Lichtman (FAS/Molecular & Cellular Biology, Center for Brain Science) and Clay Reid (HMS/Neurobiology, Center for Brain Science)

Description

The overall goal of the Connectomeproject is to map, store, analyze and visualize the actual neural circuitry of the peripheral and central nervous systems in experimental organisms, based ona very large number of images from high-resolution microscopy. The proposingteam from the Center for Brain Sciences has already demonstrated its capacityfor, and expertise in, high-throughput imaging. The critical challenges arecomputational, as the total number of voxels needed to establish the Connectomeis ~1014. The principal challenges are to develop: (a) algorithmsfor efficient 3D segmentation circuit identification (b) the ability to transfer, storeand analyze 3D images in multi 100GB range; and (c) scalable database techniques to store, manageand query multi-TB, multi-modal datasets.